molecular-evolution

Conservation and modularity in the pan-bacterial psp stress response system

An integrative computational evolutionary approach to accelerate the discovery of molecular targets in prevalent under-studied pathogens

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Bacterial Stress Response

Studying stress response systems using molecular evolution and phylogenetics.

Using computational appraches to understand host-pathogen biology

Variations on a theme: evolution of the phage-shock-protein system in Actinobacteria

The Psp system of Mycobacterium tuberculosis integrates envelope stress-sensing and envelope-preserving functions

The bacterial envelope integrates essential stress-sensing and adaptive functions; thus, envelope-preserving functions are important for survival. In Gram-negative bacteria, envelope integrity during stress is maintained by the multi-gene Psp …