stress-response

The phage shock protein (PSP) envelope stress response: discovery of novel partners and evolutionary history

Bacterial phage shock protein (PSP) systems stabilize the bacterial cell membrane and protect against envelope stress. These systems have been associated with virulence, but despite their critical roles, PSP components are not well characterized …

Computational approaches to study molecular pathogenesis and intervention of infectious diseases

MolEvolvR: A webapp for characterizing proteins using molecular evolution and phylogeny

Studying how bacterial pathogenic proteins evolve can help identify lineage-specific and pathogen-specific signatures and variants, and consequently, their functions. We have developed a streamlined computational approach for characterizing the …

MolEvolvR: Web-app and R-package for characterizing proteins using molecular evolution and phylogeny

Molecular evolution and phylogeny can provide key insights into pathogenic protein families. Studying how these proteins evolve across bacterial lineages can help identify lineage-specific and pathogen-specific signatures and variants, and …

Using a computational molecular evolution and phylogeny to study pathogenic proteins

Background: Studying bacterial physiology, adaptation, and pathogenicity through the lens of evolution requires delineating the phylogenetic history of bacterial proteins and genomes. Moreover, delineating this history of proteins is best done at all …

Computational evolutionary approaches to characterize bacterial proteins

Molecular Evolution and Phylogeny

The Staphylococcus aureus cystine transporters, TcyABC and TcyP, facilitate nutrient sulfur acquisition during infection

Computational approaches for understanding host–pathogen biology

Conservation and modularity in the pan-bacterial psp stress response system