Discovery of a predominant and distinct lineage of Mycobacterium tuberculosis in Brazilian indigenous population

After nearly a century of vaccination and six decades of drug therapy, tuberculosis (TB) kills more people annually than any other infectious disease. Substantial challenges to disease eradication remain among vulnerable and underserved populations. …

Host-responses to infection

Characterizing host response to infection and host-directed interventions

Studying lipid metabolism deregulation in TB

Summary We also studied host responses to M. tuberculosis infection using computational approaches: characterizing the transcriptional response in infected macrophages under various small molecule perturbations using RNA-Seq analysis; understanding the dysregulation of lipid metabolism in M. tuberculosis-infected macrophages using dynamic Bayesian model and statistical analyses of heterogeneous single-cell populations. Collaborators Rutgers University Marila Gennaro Sanjay Tyagi Eduardo Sontag (now in North Eastern) Tulane University Deepak Kaushal Knowledge Synthesis Hugh Salamon

The Psp system of Mycobacterium tuberculosis integrates envelope stress-sensing and envelope-preserving functions

The bacterial envelope integrates essential stress-sensing and adaptive functions; thus, envelope-preserving functions are important for survival. In Gram-negative bacteria, envelope integrity during stress is maintained by the multi-gene Psp …

Cutting edge: Vitamin D regulates lipid metabolism in Mycobacterium tuberculosis infection