Studying lipid metabolism deregulation in TB

Summary

We also studied host responses to M. tuberculosis infection using computational approaches:

• characterizing the transcriptional response in infected macrophages under various small molecule perturbations using RNA-Seq analysis;
• understanding the dysregulation of lipid metabolism in M. tuberculosis-infected macrophages using dynamic Bayesian model and statistical analyses of heterogeneous single-cell populations.

Collaborators

Rutgers University

• Marila Gennaro
• Sanjay Tyagi
• Eduardo Sontag (now in North Eastern)

Tulane University

• Deepak Kaushal

Knowledge Synthesis

• Hugh Salamon