host/pathogen

MolEvolvR: a web-app for characterizing proteins using molecular evolution and phylogeny

Studying proteins through the lens of evolution can help identify conserved features and lineage-specific variants, and potentially, their functions. MolEvolvR (http://jravilab.org/molevolvr) is a web-app that enables researchers to run a …

DciA helicase operators exhibit diversity across bacterial phyla

A fundamental requirement for life is replication of an organism’s DNA. Studies in Escherichia coli and Bacillus subtilis have set the paradigm for how DNA replication occurs in bacteria. During replication initiation in E. coli and B. subtilis, the …

Novel Internalin P homologs in Listeria ivanovii londoniensis and Listeria seeligeri

Listeria monocytogenes (Lm) is a bacterial pathogen that causes listeriosis in immunocompromised individuals, particularly pregnant women. Several virulence factors support the intracellular lifecycle of Lm and facilitate cell-to-cell spread, …

A Broadly Conserved Deoxycytidine Deaminase Protects Bacteria from Phage Infection

The glutathione import system satisfies the Staphylococcus aureus nutrient sulfur requirement and promotes interspecies competition

Sulfur is an indispensable element for proliferation of bacterial pathogens. Prior studies indicated that the human pathogen, Staphylococcus aureus utilizes glutathione (GSH) as a source of nutrient sulfur; however, mechanisms of GSH acquisition are …

Discovery of a predominant and distinct lineage of Mycobacterium tuberculosis in Brazilian indigenous population.

After nearly a century of vaccination and six decades of drug therapy, tuberculosis (TB) kills more people annually than any other infectious disease. Substantial challenges to disease eradication remain among vulnerable and underserved populations. …

sRNA discovery

Discovering unique pathogenic sRNA in infected hosts

Phage-shock-protein (Psp) Envelope Stress Response: Evolutionary History & Discovery of Novel Players

The Staphylococcus aureus cystine transporters, TcyABC and TcyP, facilitate nutrient sulfur acquisition during infection

Variations on a theme: evolution of the phage-shock-protein system in Actinobacteria