After nearly a century of vaccination and six decades of drug therapy, tuberculosis (TB) kills more people annually than any other infectious disease. Substantial challenges to disease eradication remain among vulnerable and underserved populations. …
Integrating molecular evolution and comparative genomics to achieve comprehensive, multiscale characterization of bacterial proteins and genomic features.
Discovering unique pathogenic sRNA in infected hosts
Studying stress response systems using molecular evolution and phylogenetics.
Accessory sigma factors, which reprogram RNA polymerase to transcribe specific gene sets, activate bacterial adaptive responses to noxious environments. Here we reconstruct the complete sigma factor regulatory network of the human pathogen …
Characterizing host response to infection and host-directed interventions
The bacterial envelope integrates essential stress-sensing and adaptive functions; thus, envelope-preserving functions are important for survival. In Gram-negative bacteria, envelope integrity during stress is maintained by the multi-gene Psp …