Bacterial Stress Response
Summary
I started working on bacterial stress responses during my postdoctoral research at Rutgers University, I continue to focus on using computational evolutionary approaches to study various facets of pathogen biology including:
- delineating the molecular mechanism underlying a newly identified stress response operon in the tubercle bacterium involving the phage-shock-proteins (psp);
- unraveling the evolution of bacterial stress response systems (psp) across the tree of life using protein sequence-structure-function relationships;
- reconstructing and analyzing the mycobacterial sigma factor regulatory network.
Students
- Samuel Chen (Alumni)
Collaborators
- Marila Gennaro (Rutgers)
- L Aravind (NCBI, NIH)
- Vivek Anantharaman (NCBI, NIH)
Janani Ravi
Assistant Professor
My research interests include computational pathogenomics and host-directed drug-repurposing.
Publications
Reconstruction and topological characterization of the sigma factor regulatory network of Mycobacterium tuberculosis
Accessory sigma factors, which reprogram RNA polymerase to transcribe specific gene sets, activate bacterial adaptive responses to …
The Psp system of Mycobacterium tuberculosis integrates envelope stress-sensing and envelope-preserving functions
The bacterial envelope integrates essential stress-sensing and adaptive functions; thus, envelope-preserving functions are important …
Talks
MolEvolvR: Web-app and R-package for characterizing proteins using molecular evolution and phylogeny
Molecular evolution and phylogeny can provide key insights into pathogenic protein families. Studying how these proteins evolve across …
Using a computational molecular evolution and phylogeny to study pathogenic proteins
Background: Studying bacterial physiology, adaptation, and pathogenicity through the lens of evolution requires delineating the …
