Bacterial Stress Response
I started working on bacterial stress responses during my postdoctoral research at Rutgers University, I continue to focus on using computational evolutionary approaches to study various facets of pathogen biology including:
- delineating the molecular mechanism underlying a newly identified stress response operon in the tubercle bacterium involving the phage-shock-proteins (psp);
- unraveling the evolution of bacterial stress response systems (psp) across the tree of life using protein sequence-structure-function relationships;
- reconstructing and analyzing the mycobacterial sigma factor regulatory network.
- Samuel Chen (Alumni)
- Marila Gennaro (Rutgers)
- L Aravind (NCBI, NIH)
- Vivek Anantharaman (NCBI, NIH)
My research interests include computational pathogenomics and host-directed drug-repurposing.
- The Psp system of Mycobacterium tuberculosis integrates envelope stress-sensing and envelope-preserving functions
- Variations on a theme: evolution of the phage-shock-protein system in Actinobacteria
- Using computational appraches to understand host-pathogen biology
- Reconstruction and topological characterization of the sigma factor regulatory network of Mycobacterium tuberculosis
- Host-responses to infection