pathogenic-features

MolEvolvR: a web-app for characterizing proteins using molecular evolution and phylogeny

Studying proteins through the lens of evolution can help identify conserved features and lineage-specific variants, and potentially, their functions. MolEvolvR (http://jravilab.org/molevolvr) is a web-app that enables researchers to run a …

DciA helicase operators exhibit diversity across bacterial phyla

A fundamental requirement for life is replication of an organism’s DNA. Studies in Escherichia coli and Bacillus subtilis have set the paradigm for how DNA replication occurs in bacteria. During replication initiation in E. coli and B. subtilis, the …

Novel Internalin P homologs in Listeria ivanovii londoniensis and Listeria seeligeri

Listeria monocytogenes (Lm) is a bacterial pathogen that causes listeriosis in immunocompromised individuals, particularly pregnant women. Several virulence factors support the intracellular lifecycle of Lm and facilitate cell-to-cell spread, …

Computational approaches to study molecular pathogenesis and intervention of infectious diseases

MolEvolvR: A webapp for characterizing proteins using molecular evolution and phylogeny

Studying how bacterial pathogenic proteins evolve can help identify lineage-specific and pathogen-specific signatures and variants, and consequently, their functions. We have developed a streamlined computational approach for characterizing the …

Using a computational molecular evolution and phylogeny to study pathogenic proteins

Background: Studying bacterial physiology, adaptation, and pathogenicity through the lens of evolution requires delineating the phylogenetic history of bacterial proteins and genomes. Moreover, delineating this history of proteins is best done at all …

S-layers: the proteinaceous multifunctional armours of Gram-positive pathogens.

A Broadly Conserved Deoxycytidine Deaminase Protects Bacteria from Phage Infection

The glutathione import system satisfies the Staphylococcus aureus nutrient sulfur requirement and promotes interspecies competition

Sulfur is an indispensable element for proliferation of bacterial pathogens. Prior studies indicated that the human pathogen, Staphylococcus aureus utilizes glutathione (GSH) as a source of nutrient sulfur; however, mechanisms of GSH acquisition are …

MolEvolvR: a web-app for molecular evolution and phylogeny

We will discuss the alpha version of their new easy-to-use interactive webapp: MolEvolvR, for characterizing proteins using molecular evolution and phylogeny. We will begin by demonstrating the power of MolEvolvR using the panbacterial stress response system, PSP (phage shock protein), as an example. Then, we will anyone can use this app to study their protein(s) of interest. PSP app: jravilab.shinyapps.io/psp-evolution (bioRxiv 2020) MolEvolvR app: jravilab.org/molevolvr (currently, alpha-version)