Bacterial Stress Response
Summary
I started working on bacterial stress responses during my postdoctoral research at Rutgers University, I continue to focus on using computational evolutionary approaches to study various facets of pathogen biology including:
- delineating the molecular mechanism underlying a newly identified stress response operon in the tubercle bacterium involving the phage-shock-proteins (psp);
- unraveling the evolution of bacterial stress response systems (psp) across the tree of life using protein sequence-structure-function relationships;
- reconstructing and analyzing the mycobacterial sigma factor regulatory network.
Students
- Samuel Chen (Alumni)
Collaborators
- Marila Gennaro (Rutgers)
- L Aravind (NCBI, NIH)
- Vivek Anantharaman (NCBI, NIH)
Janani Ravi
Assistant Professor
My research interests include computational pathogenomics and host-directed drug-repurposing.
Publications
The phage shock protein (PSP) envelope stress response: discovery of novel partners and evolutionary history
Bacterial phage shock protein (PSP) systems stabilize the bacterial cell membrane and protect against envelope stress. These systems …
Reconstruction and topological characterization of the sigma factor regulatory network of Mycobacterium tuberculosis
Accessory sigma factors, which reprogram RNA polymerase to transcribe specific gene sets, activate bacterial adaptive responses to …
The Psp system of Mycobacterium tuberculosis integrates envelope stress-sensing and envelope-preserving functions
The bacterial envelope integrates essential stress-sensing and adaptive functions; thus, envelope-preserving functions are important …
Talks
MolEvolvR: Web-app and R-package for characterizing proteins using molecular evolution and phylogeny
Molecular evolution and phylogeny can provide key insights into pathogenic protein families. Studying how these proteins evolve across …
Using a computational molecular evolution and phylogeny to study pathogenic proteins
Background: Studying bacterial physiology, adaptation, and pathogenicity through the lens of evolution requires delineating the …
