Discovering unique pathogenic sRNA in infected hosts
Studying stress response systems using molecular evolution and phylogenetics.
Summary We also studied host responses to M. tuberculosis infection using computational approaches:
characterizing the transcriptional response in infected macrophages under various small molecule perturbations using RNA-Seq analysis; understanding the dysregulation of lipid metabolism in M. tuberculosis-infected macrophages using dynamic Bayesian model and statistical analyses of heterogeneous single-cell populations.
Mathematical modeling of pathways involved in cell cycle regulation and differentiation