Integrating molecular evolution and comparative genomics to achieve comprehensive, multiscale characterization of bacterial proteins and genomic features.
Discovering unique pathogenic sRNA in infected hosts
Studying stress response systems using molecular evolution and phylogenetics.
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Characterizing host response to infection and host-directed interventions
Summary We also studied host responses to M. tuberculosis infection using computational approaches:
characterizing the transcriptional response in infected macrophages under various small molecule perturbations using RNA-Seq analysis; understanding the dysregulation of lipid metabolism in M. tuberculosis-infected macrophages using dynamic Bayesian model and statistical analyses of heterogeneous single-cell populations. Collaborators Rutgers University Marila Gennaro Sanjay Tyagi Eduardo Sontag (now in North Eastern) Tulane University Deepak Kaushal Knowledge Synthesis Hugh Salamon
Mathematical modeling of pathways involved in cell cycle regulation and differentiation